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2+ homeostasis, mitochondrial membrane potential, oxidative stress (as indicated by glutathione depletion and reactive oxygen species (ROS) production), and apoptosis

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Sheteiwy MS, El-Sawah AM, Kobae Y, Basit F, Holford P, Yang H, El-Keblawy A, Abdel-Fattah GG, Wang S, Araus JL, Korany SM, Alsherif EA, AbdElgawad H

Based on the results (Fig

These radicals can further damage mitochondrial DNA, proteins, and lipids, impairing mitochondrial function and reducing ATP production, which is essential for cardiac muscle contraction [87]