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This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation

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In further support of the connection between inflammageing, senescent cell burden and NAD + , a recent study in mice has also shown that cells with dysfunctional mitochondria initiate a proinflammatory programme, with the secretion of proinflammatory cytokines

As there is little research in the use of CO 2 laser for treating pillar pain, this study will help to substantiate CO 2 laser as a potential analgesic treatment modality