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Regulation of immune functions by non-neuronal acetylcholine (ACh) via muscarinic and nicotinic ACh receptors

Protein samples were then quantified for normalization (Bio-Rad Protein Assay, 5000001, Bio-Rad, CA, USA)

Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604