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It may be used in in vitro studies or approved preclinical animal models

This suggests that the oral supplement used in this study may be a reasonable alternative to subcutaneous injections of methyl-B12

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We assumed that each data element requires 0.3 minutes of clinician time to complete

A corresponding moderate increase in the functional metabolic biomarkers plasma methymalonic acid and homocysteine suggests that some depletion of maternal intracellular vitamin B12 has occurred even though serum B12 concentrations are high (Varsi et al., 2018)

If deficiency is confirmed, treatment is typically clinician-supervised and intramuscular