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3E), while molecular functions such as ion transmembrane transporter activity, peptidase activity, and calcium binding were significantly represented (Fig

J Appl Physiol 76: 2570-2577, 1994 Laaksonen DE, Atalay M, Niskanen L, Uusitupa M, Hanninen O, Sen CK: Increased resting and exercise-induced oxidative stress in young IDDM men

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Sengupta S, Peterson TR, Sabatin i DM

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Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy