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J Pharm Pharmacol 75:11191129 Ahmed T, Javed S, Javed S, Tariq A, amec D, Tejada S et al (2017) Resveratrol and Alzheimers disease: mechanistic insights

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10.5604/20831862.894649 56 MargaritisI.RousseauA

There has been a great deal of interest in the link between elevated levels of homocysteine, a direct consequence of vitamin B 12 deficiency, and cardiovascular disease

2 Exposome The exposome (Figure 1) encapsulates all of the environmental (non-genetic) exposures experienced by an individual from an array of dietary, lifestyle, and demographic factors throughout the lifespan that impact health outcomes (Wild, 2005)

A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45