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We then focus on the effects of mitochondrial metabolites, metabolic remodeling, chronic inflammation, and immune responsesthat are regulated by mitochondrial stress signaling in cellular senescence

Mechanistically, CPT1A restrains ubiquitination and degradation of c-Myc, while c-Myc transcriptionally activates CPT1A expression

These in vivo tests showed that oral administration of the extract improved memory functions, and ex vivo confirmed that the active compounds of the extract, such as eleutheroside M and ciwujianoside B and C3, were able to penetrate the BBB and act on the brain

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This pathway serves as an alternative elimination route, but the short supply of glycine in the obese state may impair glycine conjugation and compromise this detoxification system