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PMID: 39204186 Medical Disclaimer The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment

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Employing a lipophilic prodrug charge masking approach to change the polarity of hydrophilic peptides, such as with lipid derivatives of cyclic N-methylated hexapeptide containing Arg-Gly-Asp (RGD) showed that the derivatized peptides traversed mucosal membrane via the transcellular pathway in the Caco cell model to enhance polar peptide permeability [77]

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