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Description
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Pyruvate kinase deficiency varies significantly in severity, from a mild, compensated condition requiring little intervention to a severe disease requiring transfusions
The SKP1-CUL1-Fbox protein (SCF) ubiquitin ligase complex containing FBXO11 induces ubiquitination and degradation of BCL-6
Demonchy et al., 2024)
This results in the release of stored iron to further increase reactive intracellular iron levels (47)
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