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10.1016/j.pscychresns.2019.05.003 Psychiatry Res

Effects of Dietary Silica Nanoparticle on Growth Performance, Protein Digestibility, Hematology, Digestive Morphology, and Muscle Composition of Nile Tilapia, Oreochromis niloticus . Frontiers in Marine Science 8: 706179

This deficiency can be caused by poor dietary consumption, a breakdown in the digestive process, or from taking certain medications that make it difficult to absorb B12 (such as antacids)

10.1007/BF01011851 113

Genistein, a broad spectrum tyrosine kinase inhibitor, inhibits hDOR desensitization promoted by DPDPE, deltorphin I, and etorphine (Marie et al., 2008)
There are theoretical concerns, like a potential connection to cancer, that can't be dismissed without more research
