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& Lauterburg, B

These results suggested that in the cellular context, the ASXL1 1-645 cancer-linked truncation variant shows an increased ability to bridge BRD4 to some ASXL1-regulated genes, and the ASXL1 1-591 truncation may be less efficient in linking BRD4

Such trials are necessary to determine whether the promise shown in preclinical research translates to meaningful human benefit and to establish safe, effective dosing protocols

A., Arrese, M

Others argue that systemic administration is just as effective and much simpler

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