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While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)

For this reason, First-in-Human trials are not only a procedural milestone in drug development

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Cancer Cell 21 , 297308 (2012)

Insoluble In Diethyl Ether Description : Overview of L-Glutathione L-Glutathione is a tripeptide antioxidant composed of glutamine, cysteine, and glycine