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Manic episodes are associated with hyperdopaminergic and depressive episodes with reduced dopaminergic transmission [103], and the KD contributes to altered levels of monoamine metabolites, including a significant reduction in dopamine [75]

151,152 However, the properties of wild-type LAB are often uncontrollable and may not achieve the desired therapeutic outcomes

Eur J Endocrinol (2013) 168:53341

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Drug Targets 2021, 21 (2), 365373
