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ER stress leads to the activation of three ER-resident transmembrane proteins: activating transcription factor-6 (ATF6), inositol requiring protein-1 (IRE1) and protein kinase RNA-like ER kinase (PERK) (Szegezdi et al., 2006

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Mol Cell Biol 36:693713 Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P et al (2017) UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

Time points are mean SEM plasma concentrations, and a zero-inflated linear mixed-effects model was used to compare subjects before and after antibiotic exposure