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As of the time of writing, both agents remain in clinical development and have not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)

Strongly increase keratinocyte proliferation

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demonstrated that cell lines treated with foretinib and erlotinib or lapatinib [EGFR/human epidermal growth factor (HER) 2 inhibitor] synergistically inhibit HNSCC growth [100]

These results suggest that ZIL might gradually be concentrated near the surface of cells while ice crystals grow below 0 C, and then the concentrated ZIL solution may adequately dehydrate the cells