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Here the authors specifically examine deletion of a glutathione synthetic enzyme in the liver of adult mice and show that lack of glutathione affects lipid abundance through repressing NRF2.

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Animal model research reveals remarkable efficacy in both accelerated and natural aging conditions, with XpdTTD/TTD mice (accelerated aging model) showing restoration of multiple age-related deficits including fitness, fur density, and renal function following FOXO4-DRI administration

Glutathione is a naturally occurring tripeptide composed of glutamine cysteine and glycine