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While its hepatic expression remains relatively unchanged in the early stages of MASLD [290, 305], miR-21 levels were significantly elevated in patients with MASLD compared to healthy controls and individuals with steatosis [312]

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Considering that glutathione is involved in the elimination of harmful substances such as: alcohol, drugs, solvents, pesticides, heavy metals, and many other toxic xenobiotic products that induce a state of cellular stress [71], it is evident that glutathione homeostasis becomes more relevant, because cells require an antioxidant agent that either prevents or reduces this stress, whether by trapping, metabolizing or turning them into less toxic agents [71,101]

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