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Stress conditions promoting instability and denaturation of proteins induce the release of HSF-1, which the activity is associated with the expression of HSP70 in the myocardium, skeletal muscle, and human leucocytes [76, 107]

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FIGURE 1 3.1.2 Transcriptional regulation of GPX4 by the Nrf2 pathway Nuclear factor erythroid 2-related factor 2(Nrf2), is a master transcriptional regulator of the cellular response to oxidative stress

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