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This is attributable to multiple individual trials competing for the same pool of participants, growing sample size demands and the increased availability of licensed alternative options for many potential participants

Appendix A Supplementary data to this article can be found online at

In these cases, we may suggest B12 shots to help prevent or reverse a deficiency

Additionally, Pernicious anemia, an autoimmune condition affecting the stomachs ability to produce intrinsic factor (a protein necessary for B12 absorption), can also lead to deficiency

This makes it extraordinarily sensitive to changes in hormonal signaling