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The duration of the effects of a B12 injection can vary

Treatment with high dose vitamin B12 been shown to be safe for more than 50 years Out of fear of overdosing vitamin B12, treatment is often reduced to below the frequency that is needed by the patient, or, even worse, treatment is stopped completely

Because bacteriostatic water supports multiple withdrawals, it significantly reduces the need for frequent replacement

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If significant deficiency is confirmed via blood test, a loading dose protocol may be recommended in line with NICE guidance typically more frequent injections over the initial weeks to rapidly restore levels