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The hallmarks of cancer
For instance, overexpression of epidermal growth factor receptor ( EGFR ) is more common in lung cancer among never smokers (Pallis 2013a
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B: However, in the endothelial cells with high level of phosphor AKT, following the block of VEGF stimulation, the AKT pathway remains active inducing transcription of FGF, an angiogenic factor, which on one side promotes endothelium proliferation and on the other further phosphorylates AKT producing a positive loop
