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J Addict Dis

Some studies suggest that very long-term use (years of high doses) could potentially lower zinc levels

26 Within the TME, cancer cells can establish an immunosuppressive metabolic microenvironment by depriving immune cells of vital metabolites such as glucose and oxygen while also elevating the levels of mediators such as lactate and adenosine that limit the function of immune cells

doi: 10.1192/bjp.211.2.117
