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doi: 10.1016/j.ejphar.2016.03.014 141

3.2.5 Extracellular vesicles and exosomes Mesenchymal stem cells (MSCs) have been investigated for their role in organ protection in sepsis and acute respiratory distress syndrome (ARDS), primarily due to their ability to secrete beneficial exosomes that can transfer mitochondria or mitochondrial components to other cells (142)

As of the current literature, published peer-reviewed studies have primarily utilized the unmodified AEDG peptide (Epithalon) or the parent extract epithalamin

Transl Psychiatry 12:329 Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR (2021) Structural insights into the inhibition of glycine reuptake

Acknowledgements The work was supported by Research group grant 1-439-6079 from Deanship of Scientific Research, Taif University, SA

Similarly, ROS has been shown to contribute to EndMT, suggesting potential crosstalk between glutaminolysis, ROS, and mTORC1 signaling in the initiation of EndMT (Thuan et al., 2018)
