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TLR4-mediated recognition of S protein may initiate receptor dependent internalization and explain SARS-CoV-2 infection in patients and cells lacking or deficient in ACE2 expression (Aboudounya and Heads, 2021

Mol Genet Metab 102(2):126133

Smoking has consistently been associated with increased CSVD risk through mechanisms involving endothelial dysfunction, oxidative stress, inflammation, and impaired vascular reactivity

Increased formation of ROS in mitochondria is a typical phenomenon in diabetic patients with cardiovascular diseases, typically with left ventricular hypertrophy and diastolic dysfunction (Jeong et al

Recent studies demonstrated that estrogen and ER exhibit protective antioxidant effects, primarily by promoting FGF2 production, which protects Mller and other retinal cells from oxidative damage

This impairs the function of the filtration barrier, causes proteinuria and activates the complement system (Liu J