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Over 200 distinct mitochondrial redox compounds have been identified from a single blood draw for fingerprinting (Chen et al., 2019)

We speculate that sensitivity is greatest at earlier timepoints where cells must import cystine to rapidly synthesize GSH and meet demand as discussed above

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NR1H4 mRNA is expressed across a wide range of tissues

Apoptosis by the extrinsic/death receptor pathway The extrinsic apoptotic pathway is triggered by the combination of ligands, including TNF-, FasL, and TRAIL, and the corresponding death receptors (TNF- receptor 1, Fas/CD95/APO1, and TRAIL-R, respectively) on the cell surface

2016;42:e21713