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releasing diffusible signals, such as nitric oxide, prostanoids, and ions that in turn regulate blood flow [27]

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

J Endocrinol Invest 37:12331235 Ethics declarations Conflict of interest The authors declare that they have no conflict of interest

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Studies comparing combination therapy to individual peptides show enhanced reduction of inflammatory markers and improved preservation of tissue function, particularly in chronic inflammatory conditions where both protection and repair are needed simultaneously