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Description
The pathophysiology of MELAS is complex, involving heteroplasmic mtDNA mutations that result in varying degrees of tissue dysfunction, particularly in energy-demanding organs such as the brain and skeletal muscles [2]
doi: 10.1038/nm.4517 190 OoijevaarRETerveerEMVerspagetHWKuijperEJKellerJJ
every year
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von Delft, F
However, results vary considerably across different populations and conditions