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In patients with RF, plasma concentrations of the cytokines TNF, interleukin IL-6, and IL-8 were measured as sharply increasing at 24 hours after penicillin treatment when patients were experiencing a JHR, with a return toward baseline levels 12 hours after therapy (Figure 1 )
They also tend to have higher rates of pneumonia and bronchitis
doi: 10.1038/ni.3462 89 MizunoRKawadaKSakaiY
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