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Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE

These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

Temko JE, Bouhlal S, Farokhnia M, Lee MR, Cryan JF, Leggio L

9 Redox nanotechnology and glutathione-responsive therapies Redox nanotechnology leverages the abnormal oxidativereductive balance found in tumors to enable precise, stimulus-responsive treatments