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Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia
Recent breakthrough research in 2024 demonstrated that 5-amino-1MQ combined with exercise training in aged murine models produced enhanced adaptations compared to exercise alone, with grip strength improvements of approximately 60% and alterations in daily locomotor activity patterns with modified recovery kinetics
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771
Diabetes, Obesity and Metabolism
