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Oxidized thioredoxin (Trx-S2) can be reduced by NADPH through the catalytic action of the TrxR (113)

While this process is unavoidable as we age, it can be slowed, or even reversed, and glutathione (GSH) plays an important role
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doi:10.1007/s00408-013-9511-3 Iftikhar IH, Bittencourt L, Youngstedt SD, et al
doi: 10.1080/23312009.2018.1440894 99 SaperR

Bioorg Med Chem 25(24):64356449 Chuai H et al (2021) Small molecule selenium-containing compounds: recent development and therapeutic applications
