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However, such efforts have led to identify several important enzymes and key intermediates

Yoo DY, et al

The modulation of these pathways may alleviate OA symptoms ( New research has highlighted that lipid metabolism may contribute to the development and progression of OA ( in vivo and in vitro to reduce cartilage cholesterol accumulation in OA cartilage through the intermediary of the SIRT1/foxO1 pathway, hence slowing the evolution of OA ( At present, there is no compound targeting mitochondria that is likely to treat OA ( Table 2 summarizes different metabolic processes therapeutic effects, implications, and prospective therapy methods in OA