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Lipids required for ATG8 lipidation and membrane extension are delivered to the phagophore via ATG2 and ATG9, where ATG9 acts as a seed to initiate lipid transfer by ATG2 that acts as a hose funneling lipids from relevant compartments (e.g., the ER) to the phagophore (5254, 7678) ( Figure 1 , panel 3)

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However, while vertebroplasty greatly increases the failure strength of augmented vertebrae, a significantly increased risk of adjacent vertebral body fractures was recognized in both clinical and experimental studies 10,16,19,37