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The extrinsic pathway involves the activation of a protease cascade intitated by the activation of caspase 8 through the action of death receptors and their ligands, for example, FasL, and tumor necrosis factor- (181)

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In addition, research reports have been published on the determination of LAM by designing a plasma biosensor (P-FAB), which can be used alone or in combination with gold nanoparticles (AuNP) to detect LAM, thereby achieving the goal of reducing the sample size required for determination

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Interestingly, these treatments can be performed without computed tomography guidance or an anesthesiologists support, making them accessible options for many practitioners