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In clinical trials, Ipamorelin was well tolerated, with no significant effects on prolactin or cortisol secretion compared to other GHRPs. van den Berghe et al., The Journal of Clinical Endocrinology & Metabolism Rare or Potential Concerns Injection site irritation (especially with poor reconstitution technique) Overstimulation of GH axis with excessive dosing or stacking GH-related side effects at high doses (e.g., mild carpal tunnel, joint tightness) These are more likely in unsupervised high-dose or long-term protocols , especially when paired with additional GH-enhancing compounds

this estimand estimates what the effect would be if all participants adhered to treatment ** Based on the treatment policy estimand: treatment effect regardless of treatment adherence About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE programme) and as a treatment for adults with type 2 diabetes (REIMAGINE programme)

It is frequently utilized in studies examining satiety signaling, gastric-related pathways, and metabolic coordination, allowing researchers to investigate how peptide-driven signals influence feeding behavior and downstream metabolic responses

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Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study

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