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The mechanism of the carcinogenicity of heavy metals is thought to be related to defects in DNA repair following metal-induced oxidative stress and DNA damage

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hepaticus have been identified, including the cytolethal distending toxin (CDT) and a potent urease enzyme (43), but mutational analysis demonstrating the role of these virulence factors in colonization or hepatic diseases is available only for CDT (712)

Vector Laboratories, Burlingame, CA) was utilized

There is also evidence that Prx4 in addition to Srx plays a crucial role in enhancing RAS-RAF-MEK signaling to control cancer cell proliferation and metastasis formation [69]

Competing Interests The authors have no commercial associations that might create competing interests in connection with the submitted paper