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10.1056/nejmoa2001282 29 CDC (2020a)

Is astrocyte and microglia reactivity secondary to an initial oligodendrocyte insult or does cuprizone per se induce a toxic pro-inflammatory phenotype in those cells

Indeed, silencing -syn has led to neuroprotection in vitro upon 1-methyl-4-phenylpyridinium (MPP+) insult (Fountaine and Wade-Martins, via a lentiviral vector silenced human -syn expression in rat striatum, and siRNA directed against -syn reduced the expression of endogenous -syn after 2 weeks of infusion into the mouse hippocampus (Sapru et al., In addition to targeting -syn mRNA translation processes, an alternative approach to reduce -syn protein expression seeks to interfere with the transcription of the -syn gene

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10.1038/s41598-024-67251-y