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The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]

Dhople V, Krukemeyer A, Ramamoorthy A: The human -defensin-3, an antibacterial peptide with multiple biological functions

34 , e2207107 (2022)

PMC 5178091