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doi: 10.1016/j.ejheart.2003.12.004 21 CroninP.JoyceS

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It is well known that after proinsulin is packaged into vesicles in the Golgi apparatus (beta-granules) of pancreatic cells of Langherans islets (42), the C-peptide is removed, leaving the A-chain and B-chain bound together by disulfide bonds, thus constituting the insulin molecule