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To determine whether the impaired mitochondrial activity noted in statin-treated female mice is replicated in humans, we utilized patient-derived induced pluripotent stem cells (iPSC) from individuals who were susceptible or resistant to statin-induced new-onset diabetes (NOD) (Fig

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Cross-linkage of collagen fibrils in the colon wall increases with age, rising markedly after age 40, and appears to decrease compliance of the colon wall

We then re-examined the effect of GSH supplementation in this sub-group diabetic population to assess whether they respond differently to oral GSH supplementation compared to the younger population
