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The nuclear receptor TR3 (Nur77 or NGFI-B) is translocated to the outer mitochondrial membrane (OMM), interacts with NIX, and enters the mitochondrial space through the channel proteins Tom40 and Tom70, promoting alteration of the mitochondrial membrane potential by permeability transition pore complex ANT1-VDAC1 and induction of excessive mitophagy (Fig

Conclusion NAC exerts a protective effect against mercury-induced cytotoxicity and genotoxicity in rat lungs by scavenging mercury and modulating the expression of oxidative stress-related genes

doi: 10.1002/cbf.3019

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Meanwhile, Big Pharma has lost credibility