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The protection may be achieved because GLN restores the intestinal GSH content, normalizes the enzymatic activities of the antioxidant defense system and decreases the activation of the apoptotic pathway FASL/FAS/Caspase-3[88]

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Studies show that immune checkpoint blockade therapy activates CD8+ T cells to secrete IFN-, promoting ACSL4 growth, regulating cellular acyl-chain phospholipid-fatty acid binding to arachidonic acid (AA), and inducing tumor cell ferroptosis (110)