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(And, of course, its possible to have this type of tear AND the other type at the same time, although I havent come across this yet.) It seems very difficult to get a clear explanation anywhere of how significant these intrasubstance tears are and what constitutes a mild, moderate or severe version of one

Research suggests that under conditions of metabolic stress (such as overeating or oxidative stress), MOTS-c translocates from the mitochondria to the cell nucleus in an AMPK-dependent manner

Published online Mar 25, 2022