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In addition, peripheral BDNF levels, the most commonly used biomarker, cannot be relied on to accurately represent CNS activity due to systemic factors (e.g., inflammation, metabolic alterations, and platelet activation), thus stressing the need for direct neurotrophic biomarkers [321]

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Nevertheless, out of an abundance of caution, Life Extension recommends that people who have or have had lung cancer consult their physician before supplementing with vitamin E or NAC, especially at high doses

Rohrl C, Stangl H