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However, this imbalance of oxidants and antioxidants can damage the cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] Jimenez-Ferrer I, Bckstrm F, Dueas-Rey A, Jewett M, Boza-Serrano A, Luk KC, Deierborg T, Swanberg M

4.1.2 Link with autophagy Copper, recognized for its involvement in numerous biological processes, can induce oxidative stress and the ROS levels, potentially eliciting autophagic responses (225, 226)

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Cell-autonomous metabolic deregulation of cancer cells, or metabolic adaptation to microenvironmental cues (lack of nutrients, stromal supply, hypoxia, etc.), represent the triggering event of mitochondria overexploitation to orchestrate nutrient sensing and upload, signaling, and redox circuits