glutamine and glutathione synthesis from glycine glutamine; 'retro-control' by MYC‐driven inhibition of the glutamate‐cysteine
Description
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ROS-induced lipid peroxidation destabilizes the cellular membranes of endothelial cells, while oxidative modifications to tight junction proteins such as claudin and occludin disrupt their function, increasing BBB permeability (Figure 2) [38,143,148]
Biological functions of autophagy genes: A disease perspective
Consistent with its redox role, alterations in GSH homeostasis influence cellular sensitivity to oxidative stress, mitochondrial dysfunction, and multiple forms of regulated cell death
J.MonteggiaL
