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Arterioscler Thromb Vasc Biol (2005) 25:20628

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Allocation to simvastatin in patients with high baseline plasma IL-18 was associated with a lower probability of 28-day mortality compared with placebo (24.0% vs 36.8%

In addition to being delivered explicitly to the required tissues, they must reach the targeted cells, efficiently released into the cytoplasm, and exhibit in vivo biocompatibility