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Dietary choline and betaine and risk of CVD: A systematic review and meta-analysis of prospective studies
Initially developed as a hemorheological agent, it was first utilized in the management of peripheral vascular diseases, cerebrovascular insufficiency, diabetic neuropathy, and sickle cell disease [21]
doi: 10.1007/s11745-013-3865-4
Evidence for each component of this network comes from separate preclinical studies, and the precise mechanisms in human MASLD remain to be fully elucidated
10.1093/cvr/27.7.1237 Cardiovasc
Immunometabolism in the brain: how metabolism shapes microglial function
