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Transforming growth factor beta suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model

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These findings highlight that IPA can mitigate oxidative stress, inflammation and apoptosis in cardiomyocytes by inhibiting HDAC6/NOX2 signaling, demonstrating the potential therapeutic benefits of gut microbiota metabolites like IPA in heart failure treatment (Fig
