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Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

This means it not only mimics GLP-1 like Semaglutide but also enhances insulin secretion and fat metabolism through GIP activation

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Research on GLP-1 inhibitors has primarily focused on understanding the physiological roles of the GLP-1 system through preclinical and limited human studies

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